Carbapenem-Resistant Enterobacteriaceae

  • A woman in the U.S. died after being infected by a superbug during her visit to India, say doctors who found that the “nightmare” bacteria was resistant to all available antibiotics.
  • The infection was caused by carbapenem-resistant Enterobacteriaceae (CRE), a multidrug-resistant organism associated with high mortality.
  • While CRE are not new to the U.S., what was new in this case is that the infection was resistant or non-susceptible to all available antimicrobial drugs.
  • After the CRE, identified as Klebsiella pneumoniae, was confirmed by lab testing, an isolate from a wound specimen was sent to the CDC for further susceptibility testing and to determine the mechanism of resistance.
  • That testing confirmed the presence of New Delhi metallo-beta-lactamase (NDM-1), an enzyme that directly breaks down carbapenems, a powerful class of antibiotics that are often used to treat multidrug-resistant infections.
  • The U.S. Centres for Disease Control and Prevention’s antimicrobial testing showed the isolate was resistant to 26 different antibiotics.

Source: The Hindu

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