Epidermolysis bullosa

  • In a first, scientists have successfully treated a child suffering from extensive skin damage due to a genetic disease using transplants derived from genetically modified cells.

  • The boy suffered from Epidermolysis bullosa, a genetic skin disease that had destroyed about 80 per cent of the outermost layer of his skin.

  • After all established therapies failed, the medical team from at the Ruhr-Universitat Bochum in Germany and University of Modena in Italy decided to try an experimental approach.

  • They transplanted skin derived from genetically-modified stem cells onto the wound surfaces.

More Details:

  • Epidermolysis bullosa is the scientific name of a congenital skin disease that is currently considered to be incurable.

  • Its underlying mechanism is a defect in protein-forming genes that are essential for skin regeneration.

  • Even minor stress can result in blisters, wounds, and skin loss with scar formation.

  • Depending on disease severity, internal organs may likewise be affected, leading to critical dysfunctions.

  • The disease significantly reduces the patients’ quality of life; often it is also life-threatening.


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