- A Mumbai-based team of researchers has identified one more protein — heat shock protein 90 (HSP90) — found in human sperm that determines the ability of sperm to vigorously whip their tail and move or swim (motility) faster towards an egg to fertilise it.
- The reduced ability of sperm to move towards the egg is one of the causes of infertility in men.
About the Findings:
Studying groups of infertile men to find the causes of male infertility, the researchers observed that men with poor sperm motility have very low amounts of HSP90 in the sperm. In men with a greater percentage of highly motile sperm, the amount of the protein in the sperm was higher.
- The protein is present in two forms — HSP90 alpha and HSP90 beta. While the alpha form is present in the junction between the head and mid-piece of a sperm, the beta form is found in the tail. This is the first time the presence and abundance of the two forms of the protein in certain parts of the sperm has been reported.
- “HSP90 beta is dominant in the tail. So we thought the motility is regulated by HSP90 beta isoform
- At any time, sperm keep moving at a slow speed (basal motility) but in the presence of progesterone hormone, which is found in the female reproductive tract, the motility of sperm suddenly increases. It is this increased motility due to the hormone that helps sperm travel the long distance to reach the egg.
- To ascertain whether the protein is needed for motility, the researchers used two drugs to inhibit the protein in vitro.
- “HSP90 protein is not the only one that is responsible for motility. So inhibition of this protein alone may not affect basal motility.
- While the basal motility is not dependent on HSP90, the protein is required to increase the motility of sperm when exposed to progesterone hormone. “If a man has low amounts of HSP90 protein in his sperm, the sperm will be unable to swim upwards to the tubes and fertilize the egg because it cannot feel the effects of progesterone. This will be a cause of infertility.
- So the progesterone-driven motility requires additional machinery. One of the components is the HSP90 protein.
- The information about the crucial role of HSP90 protein can help scientists to develop drugs to make sperm move faster and forward in the female reproductive tract in people who low sperm motility.
- “At present there is no treatment for male infertility due to poor sperm motility caused by genetic causes.
- There is a possibility that this work might help the development of drugs that would help enhance sperm motility by restoring the functions of the protein.
- Conversely, contraceptives can be developed to inhibit the protein so that sperm do not move faster and reach the egg to fertilise it even in the presence of the hormone.
Source: The Hindu