- Stevioside (STE), isolated from the leaves of Honey yerba and widely used as the non-caloric natural sweeteners, can sweeten our lives in more ways than one, say scientists.
- Researchers at the Institute of Nano Science & Technology an autonomous institute of Department of Science and Technology (INST), Government of India in their recent study have found that stevioside, a natural plant-based glycoside found in leaves of Honey yerba (‘Stevia rebaudiana Bertoni’)when coated on nanoparticles can increase the efficiency of Magnetic hyperthermia-mediated cancer therapy (MHCT).
About Magnetic hyperthermia-mediated cancer therapy (MHCT)
- MHCT method of cancer therapy is based on heating the tumor tissues using magnetic nanoparticles in comparison to the routinely used surfactant moieties (oleic acid and polysorbate-80) and is based on generation of localised heat at the tumour site on exposure to AMF (alternating magnetic field) in the presence of magnetic nanoparticles.
- Coating the nanoparticles with the stevioside, a biosurfactant not only improved the cellular uptake of the nano-magnets in glioma C6 cancer cells (one of the most common and aggressive form of glial cancer cells) but also enhanced its retention time.
- Stevioside-coated nanoparticles also demonstrated successful uptake and highest cellular persistence inside the glioma cells upto 72 h.
- Thus, the research suggests that the nano-magnets are capable of being available inside the cells for a sufficient period (upto at least 72 h) during which further treatment strategies can be employed for cancer therapy, this avoiding the need to re-administer the nanomaterials.
- Stevioside stands out for being antihyperglycemic, immunomodulatory and sports antitumor action.